Biocompatible N-acetyl cysteine reduces graphene oxide and persists at the surface as a green radica

https://pubmed.ncbi.nlm.nih.gov/30892320/ Biocompatible N-acetyl cysteine reduces graphene oxide and persists at the surface as a green radical scavenger Valentina Palmieri 1, Enrique A Dalchiele, Giordano Perini, Alessandro Motta, Marco De Spirito, Robertino Zanoni, Andrea Giacomo Marrani, Massimiliano Papi
Affiliations expand PMID: 30892320 DOI: 10.1039/c9cc00429g Abstract We demonstrate that N-acetyl cysteine (NAC) reduces graphene oxide (GO) at room temperature. This represents a new green method to produce reduced GO (rGO). NAC adheres to the rGO surface as demonstrated by several spectroscopy techniques and avoids GO-mediated oxidation of glutathione. This method offers new opportunities for the production of green biocompatible rGO and NAC-based therapies. Similar articles Ginkgo biloba: a natural reducing agent for the synthesis of cytocompatible graphene.Gurunathan S, Han JW, Park JH, Eppakayala V, Kim JH.Int J Nanomedicine. 2014;9:363-77. doi: 10.2147/IJN.S53538. Epub 2014 Jan 7.PMID: 24453487 Free PMC article. Green chemistry approach for the synthesis of biocompatible graphene.Gurunathan S, Han JW, Kim JH.Int J Nanomedicine. 2013;8:2719-32. doi: 10.2147/IJN.S45174. Epub 2013 Jul 31.PMID: 23940417 Free PMC article. An in vitro evaluation of graphene oxide reduced by Ganoderma spp. in human breast cancer cells (MDA-MB-231).Gurunathan S, Han J, Park JH, Kim JH.Int J Nanomedicine. 2014 Apr 8;9:1783-97. doi: 10.2147/IJN.S57735. eCollection 2014.PMID: 24741313 Free PMC article. Oxidative stress-mediated antibacterial activity of graphene oxide and reduced graphene oxide in Pseudomonas aeruginosa.Gurunathan S, Han JW, Dayem AA, Eppakayala V, Kim JH.Int J Nanomedicine. 2012;7:5901-14. doi: 10.2147/IJN.S37397. Epub 2012 Nov 30.PMID: 23226696 Free PMC article. Preparation of a stable aqueous suspension of reduced graphene oxide by a green method for applications in biomaterials.Ji X, Song Y, Han J, Ge L, Zhao X, Xu C, Wang Y, Wu D, Qiu H.J Colloid Interface Sci. 2017 Jul 1;497:317-324. doi: 10.1016/j.jcis.2016.09.049. Epub 2016 Sep 23.PMID: 28288378 See all similar articles Cited by 5 articles Graphene Quantum Dots' Surface Chemistry Modulates the Sensitivity of Glioblastoma Cells to Chemotherapeutics.Perini G, Palmieri V, Ciasca G, D'Ascenzo M, Gervasoni J, Primiano A, Rinaldi M, Fioretti D, Prampolini C, Tiberio F, Lattanzi W, Parolini O, De Spirito M, Papi M.Int J Mol Sci. 2020 Aug 31;21(17):6301. doi: 10.3390/ijms21176301.PMID: 32878114 Free PMC article. Graphene Oxide-Linezolid Combination as Potential New Anti-Tuberculosis Treatment.De Maio F, Palmieri V, Santarelli G, Perini G, Salustri A, Palucci I, Sali M, Gervasoni J, Primiano A, Ciasca G, Sanguinetti M, De Spirito M, Delogu G, Papi M.Nanomaterials (Basel). 2020 Jul 22;10(8):1431. doi: 10.3390/nano10081431.PMID: 32707988 Free PMC article. Graphene Oxide Nano-Concentrators Selectively Modulate RNA Trapping According to Metal Cations in Solution.Palmieri V, Di Pietro L, Perini G, Barba M, Parolini O, De Spirito M, Lattanzi W, Papi M.Front Bioeng Biotechnol. 2020 May 25;8:421. doi: 10.3389/fbioe.2020.00421. eCollection 2020.PMID: 32523936 Free PMC article. Unravelling the Potential of Graphene Quantum Dots in Biomedicine and Neuroscience.Perini G, Palmieri V, Ciasca G, De Spirito M, Papi M.Int J Mol Sci. 2020 May 25;21(10):3712. doi: 10.3390/ijms21103712.PMID: 32466154 Free PMC article. Review. 3D Graphene Scaffolds for Skeletal Muscle Regeneration: Future Perspectives.Palmieri V, Sciandra F, Bozzi M, De Spirito M, Papi M.Front Bioeng Biotechnol. 2020 May 5;8:383. doi: 10.3389/fbioe.2020.00383. eCollection 2020.PMID: 32432094 Free PMC article. Review.

Biocompatible N-acetyl cysteine reduces graphene oxide and persists at the surface as a green radica